Histone H2B ubiquitination in transcription regulation
Lab Website: https://wolberger.med.jhmi.edu
Synopsis: The Wolberger lab is researching the role of ubiquitination in regulating transcription and the DNA damage response as well as how cross-talk between ubiquitination and other post-translational modifications regulates chromatin activity. They use a combination of x-ray crystallography, cryo-EM, and a variety of biophysical and biochemical approaches to gain insights into the fundamental mechanisms underlying these processes.