Biochemistry Seminar

Lab Website: https://kleiner.princeton.edu

Lab Website: http://www.fordycelab.com

Synopsis: The Fordyce lab works to understand protein-DNA binding interactions to understand and engineer pathways related to metabolism and protein signaling. The lab focuses on obtaining the thermodynamic and kinetic constants of these molecular interactions using microfluidics and extensive hardware (MITOMI and HT-MEK, MRBLEs, Dropception) 
 

Lab Website: https://sites.duke.edu/silvalab/

Synopsis: The main goal of the Silva lab is to understand ubiquitin pathways in response to the oxidative stress response pathway with the goal being to develop ubiquitin centered therapies to counter cancer cells. The lab uses molecular biology tools, protein biochemistry, proteomics, structural biology, and next generation sequencing to investigate ubiquitination in yeast cells.
 

Lab Website: http://www.kimseedlab.com/

Synopsis: The Seed lab works with V. cholerae and ICP1 (phages found with V. cholerae in cholera patients in Bangladesh)  to understand bacterial immunity and phage invasion strategies. The focus of the lab is to understand the mechanisms of phage interference by V. cholerae PLE (phage inducible chromosomal island-like element) to mediate the CRISPR-Cas system found in some ICP1 cells. 
 

Lab Website: https://mootha.med.harvard.edu/index.html

Synopsis: Lab aims to understand mitochondrial circuitry and regulation; specifically, mitochondrial mRNA processing, complex I assembly, dicarboxylate metabolism, and identification of the human genes required for oxidative phosphorylation. The lab has developed CLIC and CLIME tools alongside working with CRISPR  and genetically encoded tools (LbNOX, TPNOX, LOXCAT).

Lab Website: https://irvine-lab.mit.edu/

Synopsis: Works with immunology, biotechnology, and chemistry to develop novel treatments directly involved with the modulation of the immune system. The lab focuses on 3 main aspects: smart materials and nanotechnology in the development of vaccines, nanomaterials-enabled immunotherapy, and tools for monitoring/manipulating the immune system. 

Lab Website: https://www.fitzpatrick-lab.org/

Synopsis: Works with Cryo-EM to understand the structural basis of neurodegeneration and memory (amyloid fibres) as well as understanding protein aggregation. The Fitzpatrick lab has worked extensively on Alzheimers and more recently with the homotypic fibrillization of TMEM106B using light microscopy and Cryo-EM.

Lab Website: https://www.colorado.edu/lab/cameron/

Synopsis: The Cameron lab works to understand the processes of bacterial metabolism, photosynthesis, and CO2 fixation with emphasis on cyanobacteria. The lab uses long-term time-lapse microscopy, quantitative image analysis, etc. to investigate the function and assembly of carboxysomes and other related microcompartments in single-cells and bacterial populations.

Lab Website: http://ubiquitin.berkeley.edu/

Synopsis: Works on understanding ubiquitin dependent modifications with focus on the consequences of protein misfolding/aggregation, aberrant complex formation, and defective redox regulation.