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Abstract: Fundamental research to understand how bacteria fight viral infections uncovered the function of CRISPR-Cas programmable proteins that detect and cut specific DNA or RNA sequences. CRISPR technology is now an indispensable tool in human, animal and agricultural research. Furthermore, the FDA’s approval of a CRISPR therapy for sickle cell disease marked the beginning of a new era in healthcare. I will discuss the scientific and societal advances that will expand both the applications and impact of genome editing across the globe.

Abstract: Prominent among biophysical techniques is the optical trap, for which Arthur Ashkin (Bell Labs) received a Nobel Prize in 2018. Among the successes of optical traps have been direct measurements of the steps taken by biological motor proteins, such as kinesin, and by nucleic-acid enzymes, such as RNA polymerase. Optical traps facilitate studies of replication, transcription, and translation at the single-molecule level. They’ve been especially useful in mapping the free-energy landscapes of folding by small, structured RNAs.

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Abstract: The ocean absorbs most of the heat and about a quarter of the carbon emissions caused by human activities. These anthropogenic perturbations significantly influence the ocean circulation, with direct and critical implications for the climate system. The ocean circulation is characterized by diverse turbulence regimes that span a vast range of spatial and temporal scales.

Abstract: The planetary boundary layer (PBL), the lowest part of the atmosphere, plays a key role in regulating interactions between the land surface, clouds, and atmospheric turbulence. These interactions drive the exchange of energy, moisture, and aerosols, shaping both weather and climate. However, turbulence within the PBL adds complexity to these processes, making them challenging to understand and predict.

Abstract: How much will Earth warm in response to increasing carbon dioxide emissions?  Climate projections are highly uncertain yet have important societal implications.  Climate models are the most effective tools for making climate projections, however, their ability to reliably project climate has been hindered primarily by challenges in representing clouds in Earth’s atmosphere.  Cold clouds composed of supercooled liquid droplets and ice crystals are particularly challenging to represent in climate models due to the large number of complex micro-s

Abstract: Optically pumped magnetometers are popular because of their scalar accuracy, sensitivity, and compact design. However, their use in vector magnetometry often requires mechanical references like, e.g., a coil system, which can be prone to drifts and machining tolerances affecting vector accuracy. Common approaches to address this involve mechanical rotation of the magnetometer system for calibration.