Abstract: Living systems exhibit unique emergent properties such as self-assembly, rigidity, resilience, and robustness. In this talk, I will present results from ongoing projects that underscore the importance of understanding these collective properties in network-like soft materials and of addressing key questions in the rational design of biomimetic soft materials: Can we engineer composite soft matter to display life-like emergent properties? How can we enhance the tunability and control of such soft matter systems? And, is it feasible to activate synthetic soft materials using biological processes? I will begin by examining the potential physical mechanisms that underlie robust and resilient mechanical properties in biopolymer networks in cells and tissues. Utilizing rigidity percolation theory, we explore how the composite and heterogeneous composition influence cell and tissue mechanics, informing the creation of artificial constructs with tunable and robust mechanics. Following this, I will discuss the development of colloidal networks using functionalized clock proteins—proteins that regulate biological clocks—to engineer robust self-assembly kinetics and material properties in colloidal systems. Leveraging protein-based reaction networks allows us to endow synthetic systems with life-like properties. Our findings demonstrate how understanding the emergent structure-function properties in biological and bio-hybrid systems can support the development of biomimetic materials that not only mirror the robustness and adaptability of living systems but also offer enhanced control over their physical properties and functions.