**Special Physics Colloquium**— "Polymers and Parkinson’s: Elucidating Protein Function through Soft Matter Paradigms and Techniques"

Event Details
Event Date
Speaker Name/Affiliation
Peter J. Chung / University of Chicago
Seminar Type/Subject
Event Details & Abstracts

Despite being unequivocally linked to Parkinson’s disease, the function of a-synuclein remains unclear beyond transiently binding to the lipid membrane of synaptic vesicles (organelles filled with neurotransmitters). This is due, in part, to its intrinsically disordered nature; a-synuclein does not fold into a globular structure and instead behaves much like a biopolymer. While precluding traditional characterization methods, this makes a-synuclein incredibly amenable to investigation via a polymer physics framework. First, through purpose-designed membrane nanoparticles and advanced synchrotron X-ray methods I will demonstrate that a-synuclein binds to and collectively interacts to sterically-stabilize membrane surfaces, a biological manifestation of polyelectrolyte-stabilized colloids. I will then reconcile observed transient binding to synaptic vesicles by establishing that a-synuclein preferentially binds to osmotically-stressed membranes (a proxy for neurotransmitter-filled synaptic vesicles), a newly discovered biophysical function by which a-synuclein interrogates organelle contents. Utilizing these insights, I will contextualize a-synuclein as a guidepost that spatiotemporally directs non-equilibrium synaptic vesicles, a conferred function uniquely possible through its polymeric properties.