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Research Highlights

Published: Fri, 07/21/2017 - 2:45pm

The Perkins group has made dramatic advances in the use of Atomic Force Microscopes (AFMs) to study large single biomolecules, such as proteins and nucleic acids (DNA, RNA), that are important for life. After previously improving AFM measurements of biomolecules by orders of magnitude for stability, sensitivity and time response, the Perkins group has now developed ways to make these precision biomechanical measurements up to 100 times faster than previously possible––obtaining useful information in hours to days rather than weeks to months. 

The Perkins group uses its precision AFM technology to measure the tiny forces and structural states involved in the folding and unfolding of individual molecules of proteins and nucleic acids in their native wet, warm biological environments. How proteins fold and unfold normally––and sometimes misfold are crucial questions to understanding normal physiology and many of the most widespread and devastating diseases, such as cancers, neurodegenerative diseases, and some heart diseases. The Perkins group had already used their AFM technology to reveal new details in...

Published: Jul 16, 2015

For astrophysicists like Fellow Jeff Linsky, the Lyman-α spectral line of atomic hydrogen is a...

Published: Jul 01, 2015

A grand challenge of ultracold physics is figuring out how fermions become bosons. This is an...

Published: May 11, 2015

A wildly successful JILA (Nesbitt Group)-NIH collaboration is opening the door to studies of RNA...

Published: Apr 30, 2015

For decades after the invention of the red ruby laser in 1960, bright laser-like beams were...

Published: Apr 21, 2015

The Ye group has just improved the accuracy of the world’s best optical atomic clock by another...

Published: Apr 20, 2015

The Ye Group recently investigated what first appeared to be a “bug” in an experiment and made...

Published: Mar 23, 2015

One of the great challenges in the semiconductor and electronics industries is that as nanoscale...

Published: Mar 11, 2015

Supermassive black holes at the center of active galaxies are known as blazars when they are...

Published: Mar 02, 2015

The photoelectric effect has been well known since the publication of Albert Einstein’s 1905...

Published: Feb 27, 2015

When the Rey theory group first modeled a quantum system at JILA, it investigated the...

Published: Jan 20, 2015

Because red fluorescent proteins are important tools for cellular imaging, the Jimenez group is...

Published: Dec 10, 2014

Until recently, researchers who wanted to understand how magnetic materials work had to reserve...

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