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Research Highlights

Published: Fri, 07/21/2017 - 2:45pm

The Perkins group has made dramatic advances in the use of Atomic Force Microscopes (AFMs) to study large single biomolecules, such as proteins and nucleic acids (DNA, RNA), that are important for life. After previously improving AFM measurements of biomolecules by orders of magnitude for stability, sensitivity and time response, the Perkins group has now developed ways to make these precision biomechanical measurements up to 100 times faster than previously possible––obtaining useful information in hours to days rather than weeks to months. 

The Perkins group uses its precision AFM technology to measure the tiny forces and structural states involved in the folding and unfolding of individual molecules of proteins and nucleic acids in their native wet, warm biological environments. How proteins fold and unfold normally––and sometimes misfold are crucial questions to understanding normal physiology and many of the most widespread and devastating diseases, such as cancers, neurodegenerative diseases, and some heart diseases. The Perkins group had already used their AFM technology to reveal new details in...

Published: Apr 17, 2005

Markus Greiner, Cindy Regal, Jayson Stewart, and Debbie Jin have found the first-ever visual...

Published: Apr 10, 2005

Jason Jones, Kevin Moll, Mike Thorpe, and Jun Ye have generated the world's first precise...

Published: Apr 10, 2005

Andrew Hamilton and Jason Lisle, who received his Ph.D. in astrophysical and planetary...

Published: Apr 03, 2005

A high-powered JILA collaboration led by JILA Fellows Jun Ye and Chris Greene is making...

Published: Apr 03, 2005

Three years ago Jun Ye decided to apply an old idea for amplifying and stabilizing continuous-...

Published: Mar 31, 2005

Pete Roos, Tara Fortier, Xiaoqin Li, Ryan Smith, Jessica Pipis, and Steve Cundiff are using a...

Left to their own devices, deuterium atoms would attach themselves to cold specks of soot...

Triatomic hydrogen ion (H3+) has many talents. In interstellar clouds,...

The race is on! Two mice chase one another around a curvy, roughly elliptical white stripe....

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