Charles M. Nichols
3035 Oneal Pky. Apt. T21, Boulder, CO 80301
Expected Graduation: 8/2015
EDUCATION AND TRAINING
Ph.D. Candidate, Physical Chemistry: 08/2010-Present
University of Colorado, Boulder, CO
Advisors: Veronica M. Bierbaum & W. Carl Lineberger
Bachelor of Science, Chemistry (ACS certified): 08/2005-05/2009
University of Central Arkansas, Conway, AR
Undergraduate: Acoustics; Advanced Analytical Chemistry; Advanced Inorganic Chemistry; Biochemistry I; Biology I & II; Calculus I, II, & III; College Chemistry I & II; Differential Equations; Genetics; Introduction to Inorganic Chemistry; Organic Chemistry I & II; Organic Spectroscopy; Physical Chemistry I & II; University Physics I & II
Graduate: Advanced Molecular Spectroscopy; CIRES Electronics Course; Chemical Kinetics and Reaction Dynamics; Introduction to Quantum Chemistry; JILA Machine Shop Course; Mathematical Methods in Physical Chemistry; Peptides and Proteins in Mass Spectrometry; Statistical Mechanics
• Studied the gas-phase stability of nitrated azole compounds.
• Studied thermodynamic properties of o-, m-, and p-cresol distonic anions.
• Developed and installed an electrospray ion source for the FA-SIFT.
• Explored a number of ion-neutral reactions of the oxygen radical cation, O+•.
• Elucidated an intrinsic α-effect by studying gas-phase SN2 reactions.
• Investigated state-specific chemical reactions of Cu+.
Flowing Afterglow–Selected Ion Flow Tube; Selected Ion–Drift Cell Mass Spectrometer; Photoelectron Spectrometer; Electrospray Ionizer; Electron Impact Ionizer; Glow-Discharge Ionizer; Triple Quadrupole; Microwave Discharge; Ion Funnel
Charles Nichols, Karen Steelman and Kyle Felling; “SWRMing like Bees at the 2008 ACS Southwest Regional Meeting,” in Chemistry Magazine, 2008, April/May, 24.
John M. Garver, Zhibo Yang, Charles M. Nichols, Benjamin B. Worker, Scott Gronert and Veronica M. Bierbaum; “Resolving the α-Effect in Gas-Phase SN2 Reactions: A Marcus Theory Approach,” International Journal of Mass Spectrometry, 2012, 316, 244.
William S. Taylor, Micah L. Abrams, Cullen C. Matthews, Seth Byers, Scott Musial and Charles M. Nichols; “State-Specific Reactions of Cu+ (1S, 3D) with CH3X and CF3X (X = Cl, Br, I): Exploring the Influence of Dipole Orientation on Association and C-X Bond Activation,” The Journal of Physical Chemistry A, 2012, 116, 3979.
John M. Garver, Zhibo Yang, Nadine Wehres, Charles M. Nichols, Benjamin B. Worker, and Veronica M. Bierbaum; “The α-Effect in Elimination Reactions and Competing Mechanisms in the Gas-Phase,” International Journal of Mass Spectrometry, 2012, 330, 182.
Charles M. Nichols, Zhibo Yang, Benjamin B. Worker, Denver R. Hager, Nico M. M. Nibbering, and Veronica M. Bierbaum; “Gas-Phase Reactions of the Atomic Oxygen Radical Cation with Halogenated Compounds,” Physical Chemistry Chemical Physics, 2013, 15, 561.
Charles M. Nichols, Zhibo Yang, and Veronica M. Bierbaum; “Gas-phase Organic Reactions of the Atomic Oxygen Radical Cation,” International Journal of Mass Spectromery, 2013, 353, 1.
Ditte L. Thomsen, Jennifer N. Reece, Charles M. Nichols, Steen Hammerum, and Veronica M. Bierbaum; “Investigating the α-Effect in Gas-Phase SN2 Reactions of Microsolvated Anions,” Journal of the American Chemical Society, 2013, 135, 15508.
Ditte L. Thomsen, Charles M. Nichols, Jennifer N. Reece, Steen Hammerum, and Veronica M. Bierbaum. “The α-Effect and Competing Mechanisms: The Gas-Phase Reactions of Microsolvated Anions with Methyl Formate,” Journal of the American Society for Mass Spectrometry, 2014, 25, 159.
Ditte L. Thomsen, Jennifer N. Reece, Charles M. Nichols, Steen Hammerum, and Veronica M. Bierbaum; “The α-Effect in Gas-Phase SN2 Reactions of Microsolvated Anions: Methanol as a Solvent,” Journal of Physical Chemistry A, – In press.
Jennifer N. Reece, Ditte L. Thomsen, Charles M. Nichols, and Veronica M Bierbaum, “Study of the α-Nucleophilicity of BrO and ClO anions” – In preparation.
Daniel J. Nelson, Wilson K. Gichuhi, Charles M. Nichols, Veronica M. Bierbaum, and W. Carl Lineberger; “Structure and Thermochemistry of o-, m-, and p-Dehydromethylphenol” – In preparation.
Scott Gronert, John M. Garver, Charles M. Nichols, Benjamin B. Worker, and Veronica M. Bierbaum; “Dehalogenation of Arenes via SN2 Reactions at Bromine: Competition with Nucleophilic Aromatic Substitution” – In preparation.
Charles M. Nichols, William M. Old, W. Carl Lineberger, and Veronica M. Bierbaum, “Gas-Phase Acidities of Nitrated Azoles using the Extended Kinetic Method” – In preparation.
• Poster: “State-Specific Reactions of Cu+ (1S, 3D) with CH3X and CF3X (X = Cl, Br, I),” South West Regional Meeting of ACS; Little Rock, AR; October 2008
• Oral: “Dipole Orientation Effects on Reactions of Cu+(3D) with Substituted Methanes,” Arkansas Undergraduate Research Conference; Arkadelphia, AR; April 2009
• Oral: “Gas-Phase Reactions of the Oxygen Radical Cation,” 60th ASMS Conference on Mass-Spectrometry and Allied Topics; Vancouver, BC; May 2012
• Poster: “Gas-Phase Reactions of the Oxygen Radical Cation,” 22nd Gas-Kinetics Conference; Boulder, CO; June 2012
• Seminar: “Gas-Phase Ion Chemistry: from UCA to Graduate School,” Invited Talk; Seminar Course; University of Central Arkansas; Conway, AR; March 2013
• Seminar: “Techniques in Ion Chemistry,” Boulder Ion Supergroup; Boulder, CO; March 2013
• Poster: “Organic Reactions of the Atomic Oxygen Radical Cation,” 61st ASMS Conference on Mass-Spectrometry and Allied Topics; Minneapolis, MN; June 2013
• Seminar: “Gas-phase Acidities of Nitrated Azole Species Using the Kinetic Method,” Boulder Ion Supergroup; Boulder, CO; April 2014
• Poster: “Gas-Phase Acidities of Nitrated Azoles Using the Extended Kinetic Method,” 62nd ASMS Conference on Mass-Spectrometry and Allied Topics; Baltimore, MD; June 2014
• Oral: “Gas-Phase Acidities of Azoles: Experimental and Computational Studies,” 62nd ASMS Conference on Mass-Spectrometry and Allied Topics; Workshop on Gas-Phase Ion Chemistry; Baltimore, MD; June 2014
QUALIFICATIONS AND OUTREACH
• Volunteer: Chemistry Tutor, University of Central Arkansas (09/2007–05/2009)
• President: University of Central Arkansas Chapter of the American Chemical Society (2008)
• Recipient: Outstanding Student Award¬—Central Arkansas Section of the American Chemical Society (2008-2009)
• Research Assistant: University of Colorado, Boulder (05/2011–present)
• Teaching Assistant: University of Colorado, Boulder (08/2010 – 05/2011, 08/2012 – 12/2012)
• Recipient: Richard A. Schaeffer Memorial Travel Grant (2012)
• Volunteer: Boulder Valley School District Science Fair, Judge (3/2012)
• Manager: Chemical Inventory, Over 800 chemicals, Bierbaum Lab (6/2012–present)
• Volunteer: Partnerships for Informal Science Education in the Community (6/2012–present)
• Participant: CU Wizards, “The Magic of Chemistry,” (10/2012)
• Volunteer: Boulder Valley School District Science Fair, Head Judge (2/2014)
I am a physical/analytical chemist, specializing in mass spectrometry techniques. I am currently investigating small molecule problems in physical chemistry, and I have recently become extremely interested in biological problems. After graduation, I hope to obtain a postdoctoral position with a group that specializes in instrument development and biological applications.
I find the greatest satisfaction solving mechanical and electrical problems. I enjoy spending time in the machine shop and working on circuits. Maintaining and repairing the home-built flowing afterglow−selected ion flow tube (FA-SIFT) has advanced my understanding of instrumentation. I aspire to acquire more skills with drafting and design programs.
These passions play out in my personal life as well. In my free time, I repair audio amplifiers, as well as assemble electric guitars, electric guitar amplifiers, and guitar effects pedals. Through these hobbies, I have acquired over 200 hours of hands on experience with soldering and troubleshooting electronic circuits.
I would say I am an engineer with a chemist’s training.
PROFESSIONAL REFERENCE LIST
Veronica M. Bierbaum, Professor
Department of Chemistry and Biochemistry
University of Colorado
Boulder, CO 80309
office: (303) 492-7081
Dr. Bierbaum has been my research advisor for the last four years. We have worked closely together on many projects. She has been my mentor and has provided me with the opportunity to study several chemical systems using the FA-SIFT. As her senior graduate student, I am in charge of all maintenance and care for the FA-SIFT.
W. Carl Lineberger, Distinguished Professor of Chemistry and Biochemistry
University of Colorado
Boulder, CO 80309
office: (303) 492.7834
Dr. Lineberger has been my research advisor for the last four years. Although I work primarily in mass spectrometry, I also look at electron binding energies of anions using the Photoelectron Spectrometer in the Lineberger lab. There is a collaboration between the Bierbaum and Lineberger labs, and I work between the two.
William M. Old, Assistant Professor
Molecular, Cellular, and Developmental Biology
University of Colorado
Boulder, CO 80309
office: (303) 735-4019
Will and I first met when he was overseeing the chemistry and biochemistry department’s core mass spectrometry facility. When I came to the lab looking for a triple quadrupole, he directed me towards an offline QTrap 4000 that I restored. ince then, we have become friends, and I have been attending his group meetings where I am earning techniques in proteomics.
William S. Taylor, Professor
Department of Chemistry
University of Central Arkansas
Conway, AR 72035
office: (501) 852-2529
Bill served as my undergraduate research advisor. During my time with him, I worked on a home-built drift cell time of flight mass spectrometer. Since I have graduated, Bill and I have remained in close contact. I have helped him calculate collision rate constants, and have given him advice on optimizing his electro spray ionization source.
Police Officer and Landscaper
Smith Lawn Care LLC
37 Western Hills Cir
Greenbrier, AR 72058
cell: (501) 472-2585
I include Matt as a reference to show that I have gotten my hands dirty in the past. If you called Matt, he would tell you that I am a hard worker. When I worked for him I ran the string trimmer while he ran the lawn mower. Although Matt and I became friends, I would be lying if I said I missed that job.