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Optical control of protein activity usingengineered photoreceptors

Event Details

Event Dates: 

Wednesday, April 25, 2018 - 3:30pm

Seminar Location: 

  • JSCBB Butcher Auditorium

Speaker Name(s): 

Chandra Tucker
Seminar Type/Subject

Scientific Seminar Type: 

  • Biochemistry Seminar

Event Details & Abstract: 

While chemicaltools that allow control of protein activities and interactions have been inuse for a number of decades, a recently emerging field centers on the use oflight for protein control, allowing spatial, temporal, and reversible controlof protein activity. Here I will discuss different ways we are engineeringplant photoreceptor proteins as tools to directly control protein activity withlight. In particular, I will focus on use of the Arabidopsisphotoreceptor cryptochrome 2 (CRY2), which our lab has pioneered as anoptogenetic module. I will discuss recent work using CRY2 to regulateprotein-protein interactions, alter protein localization, modulate enzymeactivity, and disrupt/induce protein function using light.