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Research Highlights

Published: Fri, 07/21/2017 - 2:45pm

The Perkins group has made dramatic advances in the use of Atomic Force Microscopes (AFMs) to study large single biomolecules, such as proteins and nucleic acids (DNA, RNA), that are important for life. After previously improving AFM measurements of biomolecules by orders of magnitude for stability, sensitivity and time response, the Perkins group has now developed ways to make these precision biomechanical measurements up to 100 times faster than previously possible––obtaining useful information in hours to days rather than weeks to months. 

The Perkins group uses its precision AFM technology to measure the tiny forces and structural states involved in the folding and unfolding of individual molecules of proteins and nucleic acids in their native wet, warm biological environments. How proteins fold and unfold normally––and sometimes misfold are crucial questions to understanding normal physiology and many of the most widespread and devastating diseases, such as cancers, neurodegenerative diseases, and some heart diseases. The Perkins group had already used their AFM technology to reveal new details in...

Published: Nov 22, 2016

Galaxy mergers routinely occur in our Universe. And, when they take place, it takes years for...

Published: Nov 21, 2016

Graduate student Mike Thompson of the Weber group wants to understand the basic science of...

Published: Nov 11, 2016

For a long time, there’s been a mystery concerning how tiny interactions between individual...

Published: Nov 08, 2016

Fellow Mitch Begelman’s new theory says it’s possible to form stars while a supermassive black...

Published: Oct 31, 2016

Far-red fluorescent light emitted from proteins could one day illuminate the inner workings of...

Published: Oct 27, 2016

Using frequency comb spectroscopy, the Ye group has directly observed transient intermediate...

Published: Sep 26, 2016

The Nesbitt group has invented a nifty technique for exploring the physics and chemistry of a...

Published: Sep 26, 2016

Exciting new theory from the Rey group reveals the profound effects of electron interactions on...

Published: Aug 11, 2016

Graduate student Greg Salvesen, JILA Collaborator Jake Simon (Southwest Research Institute), and...

Published: Jul 28, 2016

Physics education researchers from the University of Colorado Boulder and the University of...

Published: Jul 28, 2016

Newly minted Ph.D. Ming-Guang Hu and his colleagues in the Jin...

Published: Jul 27, 2016

Fellow Phil Armitage and group collaborator Jacob Simon of the Southwest Research Institute are...

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