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Research Highlights

Published: Fri, 07/21/2017 - 2:45pm

The Perkins group has made dramatic advances in the use of Atomic Force Microscopes (AFMs) to study large single biomolecules, such as proteins and nucleic acids (DNA, RNA), that are important for life. After previously improving AFM measurements of biomolecules by orders of magnitude for stability, sensitivity and time response, the Perkins group has now developed ways to make these precision biomechanical measurements up to 100 times faster than previously possible––obtaining useful information in hours to days rather than weeks to months. 

The Perkins group uses its precision AFM technology to measure the tiny forces and structural states involved in the folding and unfolding of individual molecules of proteins and nucleic acids in their native wet, warm biological environments. How proteins fold and unfold normally––and sometimes misfold are crucial questions to understanding normal physiology and many of the most widespread and devastating diseases, such as cancers, neurodegenerative diseases, and some heart diseases. The Perkins group had already used their AFM technology to reveal new details in...

Published: Jul 10, 2017

Getting lasers to have a precise single frequency (color) can be trickier than herding cats. So...

Published: Jun 20, 2017

The Kapteyn-Murnane group has come up with a novel way to use fast bursts of extreme ultraviolet...

Published: May 22, 2017

JILA and NIST scientists are hot on the trail of understanding quantum correlations (or...

Published: Apr 21, 2017

The Regal group recently met the challenge of measurements in an extreme situation with a device...

Published: Mar 30, 2017

The first results are in from a new search for the axion, a hypothetical particle that may...

Published: Mar 20, 2017

Dennis Gardner and his coworkers in the Kapteyn-Murnane group accomplished two major...

Published: Mar 03, 2017

The lovely Crab Nebula was created by a supernova and its spinning-neutron-star remnant known as...

Published: Mar 02, 2017

The Perkins group continues to extend the performance of its unique Atomic Force Microscope (AFM...

Published: Dec 21, 2016

Research associate Shimon Kolkowitz and his colleagues in the Ye group and Rey theory group have...

Published: Dec 19, 2016

Deborah Jin, Jun Ye, and their students wrote a review during the summer of 2016 for Nature...

Published: Dec 13, 2016

Astrophysicist Jeff Linsky and his colleagues recently created a sophisticated mathematical...

Published: Dec 12, 2016

The Rey and Ye groups discovered the strange rules of...

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