The discovery of the Antarctic ozone hole shocked the world in 1985 and contributed to remarkable changes in policy as well as in chemical science and public understanding. Industrial chlorofluorocarbons (CFCs) that cause ozone depletion were phased out under the Montreal Protocol. The chemistry of ozone depletion will be reviewed, with attention to the ways in which physical chemistry contributed to science and policy. I will also summarize the evidence that observation sand model calculations taken together indicate that the onset of healing of Antarctic ozone loss has now emerged in September. Finally, I will discuss the status of discussion in amending the Montreal Protocol to include the hydrofluorocarbons (HFCs).