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Biophysical characterization of intrinsically disordered proteins

Event Details

Event Dates: 

Thursday, October 9, 2014 - 12:00pm

Seminar Location: 

  • JILA X317

Speaker Name(s): 

Loren Hough

Speaker Affiliation(s): 

University of Colorado Boulder
Seminar Type/Subject

Scientific Seminar Type: 

  • Condensed Matter Seminar

Event Details & Abstract: 

Intrinsically disordered protein domains (IDPs) are those which are thought to remain unfolded in a functional form in the cellular environment.   Some IDPs act as scaffolds the mediate protein-protein interactions, others serve as regulatory elements, others as polymer brushes prohibiting passage of most macromolecules.  However, the function of most IDPs remains unclear.  My aim is to use nuclear magnetic resonance and fluorescent techniques to probe the behavior and function of IDPs; in particular how the biophysical properties of IDPs relate to their biological function.  I'll give an informal overview of the primary three projects in my lab working towards this goal, which involve proteins involved in nucleo-cytoplasmic transport, cell division and DNA damage repair.